Famed for his booze-soaked lifestyle as much as his beautiful way with words, the Swansea-born bard remains Wales' pre-eminent poet.
Thomas loved Fitzrovia and spent much of his brief life frequenting the then-bohemian bars.
"Dylan Thomas in Fitzrovia", directed by Simon Green, is a centenary celebration of the poet in music as well as words. The charity concert premieres three new works dedicated to Wales' best-loved poet.
There will also be readings by special guests, including Owain Arwel Hughes, Camerata Wales, Robert Bathurst, Tom Hollander, Lesley Manville, John Owen-Jones, Siân Phillips, Jonathan Pryce and Griff Rhys Jones.
Local Fitzrovia charities will recieve the benefits from the gala.