Police were called to Homerton High Street at 4.20pm yesterday.
Officers and London Ambulance Service attended to find a cyclist suffering from critical injuries following a collision with a lorry.
The 34-year-old man was pronounced dead at the scene a short while later.
The driver of the HGV stopped at the scene and is helping police with their enquiries. No arrests have been made.
Some local people are calling the stretch of road a "death trap".
With reports that this is the 14th cyclist to die in Hackney in the last decade and the second on Homerton High Street in a fortnight.
London Live's Reya El-Salahi has been speaking to local cyclist Tony Johnson who narrowly avoided yesterday's fatal accident.
Officers from the Serious Collision Investigation Unit are now appealing for witnesses. Anyone with information is asked to call Crimestoppers anonymously on 0800 555 111.