More than seven and a half thousand people have signed a petition calling for an investigation into how a building in Newham has, in their words, "destroyed" the view of St Paul's Cathedral from Richmond Park.
The sightline has been cherished for the past 300 years and was legally protected in the 1990s.
But campaigners say key organisations were not informed about the construction of Manhattan Loft Gardens until it emerged on the skyline.
The developers of Manhattan Loft Gardens said they were only made aware that the building could be seen from Richmond Park very recently.
A spokesperson from Manhattan Loft Corporation said:
"At no point was the subject of visual impact to St Paul's Cathedral ever raised to us by the Olympic Delivery Authority or Greater London Authority. We went through a transparent and public process to gain lawful planning permission for which we were granted."